Symbol
Name
ID

Bmp4
bone morphogenetic protein 4
MGI:88180

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Hyperechogenic kidneys	Hydronephrosis	Renal dysplasia	Renal hypoplasia	Renal insufficiency	Hydroureter	Congenital megaureter	Ureteropelvic junction obstruction
Disease(s) Associated with BMP4	Hyperechogenic kidneys	Hydronephrosis	Renal dysplasia	Renal hypoplasia	Renal insufficiency	Hydroureter	Congenital megaureter	Ureteropelvic junction obstruction
CAKUT2
syndromic microphthalmia 6

Mouse Phenotypes

increased metanephric mesenchyme apoptosis

kidney cyst

polycystic kidney

enlarged kidney

albuminuria

abnormal renal/urinary system morphology

abnormal renal glomerulus morphology

glomerulosclerosis

abnormal kidney development

abnormal kidney mesenchyme morphology

abnormal metanephric mesenchyme morphology

abnormal nephrogenic zone morphology

dilated kidney calyx

hydronephrosis

small kidney

kidney atrophy

renal hypoplasia

duplex kidney

single kidney

abnormal ureter morphology

abnormal ureter development

abnormal ureter smooth muscle morphology

bifid ureter

dilated ureter

ectopic ureter

hydroureter

abnormal ureterovesical junction morphology

abnormal ureteral orifice morphology

absent urinary bladder

abnormal ureteric bud elongation

ectopic ureteric bud

Availability

Mouse Genotype

Bmp4^tm1Blh/Bmp4⁺

Bmp4^tm2Blh/Bmp4⁺

Bmp4^tm4Blh/Bmp4^tm4Blh
Isl1^tm1(cre)Sev/Isl1⁺ (conditional)

Tg(Actb-GFP,-Bmp4)1Csk/0
Tg(CAG-cre/Esr1*)67Csk/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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